AIM: To investigate the influence of perindopril on
insulin resistance to hypertensive rat model (high glucose high salt
fed rats(GSFR)). METHODS: Male Spraque-Darley 30 rats were divided into two groups (control group and perindopril group).The perindopril group was fed on high glucose and high salt diet(50% glucose 8% salt by weight) for 4 wk and treated with perindopril 0.8 mg·kg -1·d -1 for the later 4 wk. Another rats were fed with standard food for 8 wk. The changes of systolic blood pressure (SBP),fasting blood glucose (FBG),fasting blood insulin (FINS),insulin sensitivity index (ISI), and Na,K-ATPase activity of erythrocyte membrane of two groups before experiment, 4 wk and 8 wk were observed. RESULTS: In perindopril group of 4 wk, the SBP, FBG and FINS increased, SBP (4.4±s 1.6) kPa,FBG (0.4±0.3) mmol·L -1,and FINS(12.7±2.1) μU·L -1 , ISI decreased(1.30±0.20), and Na,K-ATPase activity decreased(12±6) nmoL·pi·mg -1pro·h -1, (P< 0.01). This indicated that
hypertension and
insulin resistance wasproduced in rars. The comparison of following times between 8 wk and 4 wk:SBP and FINS decreased, SBP((13.2±1.2)kPa vs (17.0±2.0) kPa) (P<0.01), FBG decreased ((2.9± 0.7) mmol·L -1 vs (3.8± 0.3) mmol·L -1) (P< 0.01), FINS ((8.0± 1.5) μU·L -1 vs (18±3) μU·L -1) (P< 0.01),ISI increased ((-3.20± 0.20) vs (-4.20± 0.20)) (P< 0.01)and Na,K-ATPase activity increased((26±6) nmoL·pi·mg -1pro·h -1 vs (36±9) nmoL·pi·mg -1pro·h -1) (P< 0.01). CONCLUSION: Perindopril can improve insulin resistance (IR) to the GSFR.