Objective To investigate the effects of
Anti Osteoporosis Acupoint Plaster (AOAP) on experimental
Osteoporosis (EO), and
its mechanism of antagonizing the development of
osteoporosis. Methods The rat model was established by intramuscular dexamethasone injection. The model rats were treated with AOAP by plastering the plaster on the selected acupoints and on the selected non acupoints, with drugs for tonifying the kidney as a control. The serum T/E2, bone density, CT/PTH, and the bone morphometrical indexes, such as TBV, TBS, TFS, LBGR, AFS, MAR, BFR, TRS were used as the criteria in observing the effects of AOAP.Results AOAP could increase the bone density and the levels of serum T/E2 and CT/PTH, raise the levels of TBV, TBS, TFS, LBGR, AFS, MAR and BFR, and reduce the level of TRS.Conclusion AOAP can regulate and control the incretion related with bone metabolism by multiposition correlational aggregative effect, raise the levels of T/E2 and CT/PTH, avoid the calcium loss in osteoporosis and increase bone density.