Objective To observe and compare the effect of Lycium barbarum L (LBL)and Seleniferous Lycium Barbarum L(SLBL) on the morphology of renal senility. Methods The model of senile mouse was made by subcutaneous injecting D-galactose and orall administration of 10% solution of chinese herbal medicine. Light microscopy and transmition electromicroscope were used and BI2000 image analysis system was employed for morphometric study. Results Glomerulus sclerosis rate,renal capsule breadth,renal corpuscle diameter and area,basement membrane thickness in model group were higher than those in normal control, LBL and SLBL groups (P<0.01 or 0.05). The percentage of the area of capillary lumen with that of glomerulus, the number of peritubular capillary, slit pore width in model group were lower than those in normal control, LBL and SLBL groups (P<0.01). The parameters of glomerulus sclerosis rate, the number of peritubular capillary, basement membrane thickness were different between LBL and SLBL groups(P<0.05).Conclusion SLBL was beneficial for morphology of senile kidney and has stronger delayed effect on renal senility of mouse than LBL.