Aim To study the preparation of
hydroxypropyl methylcellulose phthalate(
HPMCP)
nanoparticles and compare its pharmacokinetic characteristics with
Neoral. Methods HPMCP nanoparticles loaded cyclosporine A were prepared by solvent nonsolvent method. CyA HP50 nanoparticles, CyA HP55 nanoparticles and Neoral were orally administered at the dosage of 15 mg·kg -1 to rats. The CyA concentration in blood were determined by HPLC. Pharmacokinetic parameters were calculated by 3P97 program. Results The concentration time data of the three preparations were best fit by two compartment model. The
relative bioavailability of CyA HP50 and CyA HP55 nanoparticles calculated by the AUC 0-72 were 82 3% and 119 6%, bioequivalent to the reference of Neoral. The relative bioavailability of CyA HP55 nanoparticles was 145 3% of CyA HP50 nanoparticles. Conclusion CyA HPMCP nanoparticles could be prepared easily and reproducibly. It was found that the oral absorption of CyA can be increased by using the HPMCP nanoparticles.
More summaries about the Relative bioavailability of cyclosporine A-loaded hydroxypropyl methylcellulose phthalate nanopart