Objective:To observe the local effect of statins on the mouse calvaria osteogenesis
and
remodeling.Methethods:Thirty
mice were randomly divided into 3 groups:control group,simvastatin
group and
lovastatin group.Fifty microliters PBS,simvastatin(15 mg/ml)or lovastatin(15 mg/ml)were in-
jected subcutaneously on the direct surface of right calvaria for 4 days continuously in corresponding
group.One month later,mouse calvaria were harvested to perform
thickness measurement and fine struc-
ture observation.Results:The mean thickness of the right side of calvaria in lovastatin and simvastatin
groups was increased by 73% and 115% respectively,significantly higher than that of the control group
(P<0.01).In statin groups,the thickness of right side of calvaria was significantly higher than that of
the left side(P<0.01).While no difference was detected between the right and left sides of calvaria in
control group(P>0.05).The fine structure of the calvaria was remodeled in statin groups.Conclusion:
Local administrating statins could stimulate the mouse calvaria osteogenesis and remodeling.