Objective:To investigate the effect of combined use of
Ranitidine Bismuth Citrate(Rbc) and magnldrate on rats gastric ulcer
models,and to compare the combined effect of RBC and magnldrate with the single effect of RBC or magnldrate when used singly.Methods:Pyloric ligation induced ulcer and ethanol injury induced ulcer models were used.The models were given the mixture of RBC and magnldrate respectively;meanwhile,they were given equal distilled water.The models induced by ethanol were given RBC and magnldrate respectively.The indexes and inhibitory rates of each group were calculated and statistical analysis made.Results:In the models with ethanol induced ulcer,the inhibitory rate was 66.49% when the two medicines were used in combination,highter than that of the control group when RBC or magnldrate was used singly.In the models with pyloric ligation induced ulcer,the inhibitory rate was 42.71% when the two medicines were used in combination.There was a significant difference between this group and the control group.Conclusion: RBC and magnlclrate used in combination showed a better therapeutic effect for rats gastric ulcer than RBC or magnldrate used singly.