The survey result of Ministry of Health national hospital infection monitoring network in both 2001 and 2003 shows that meanapplication
rate of cross sectional antibiotics in hospital is over 54%, generally are joint therapy. The domestic monitor also indicates that thepathogenic bacteria resistance to drugs is increasingly growing. Aiming at the problems, article outlines several matters a clinical physician shouldthink before prescribe antibiotics: if there is indication for using antibiotics? If the antibiotics selected understood? Which drug is selected? if thereis indication for joint therapy with antibiotics? Which channel, dosage and time for drug
administration? If there is antibiotics administration forspecial host or special pathogenic bacteria infection? Closely observe if the antibiotics administration is effective or not? For local infection,puncture or surgical operation needed for focus drainage? There is adverse effect caused by antibiotics administration? Interrelation of drugs?Irrational use of antibiotics? And the article outlines the suggestions towards each problem.