One of the most interesting comic about the sport football. Not only shows the spirit of struggle, solidarity and friendship, but also many funny scenes that can make readers laugh. Eyeshield 21 told of a teenage boy named Sena Kobayakawa weak who entered school choice, Deimon Senior High, is also a school where his childhood friend, Mamori Anezaki, regarded as his brother, who received last year. Sena physical ability that is above average is just running, because as a child he often told his peers and the naughty dikerjai to buy this or that in a short time. His talent was discovered by a team of American football quarterback school, Hiruma Youichi. He cheated and forced Sena innocent until finally joined his team at that time consisted only of two people, Deimon Devil Bats, and placed on the running back position.
To protect his identity so that other clubs are not recruited because of the velocity, Sena also served as secretary of the club, and follow the game while wearing a protective helmet with green eyes to hide their identity, is used the name ''Eyeshield 21''.
Devil Bats team tournament match and then follow the spring, with hopes to win with the ''secret weapon'' of their new. But in the second game, against a team they defeated Oujou White Knights, a strong team that focuses on defense.
After the match, which Mamori overprotective and did not know about the Sena was Eyeshield 21 Sena, finally volunteered to be the manager of the club, acted to protect Hiruma Sena from the captain that was arbitrary and underhanded, but genius.
After some time, comes the game that is not less important is the fall tournament, where teams compete to play opportunity in the ''Christmas Bowl'', American Football league championships throughout high school in Japan. Hiruma, Kurita and Sena slowly build a real team by recruiting Tarou Raimon, a professional baseball player who only catch the ball, and three brothers Ha-Ha. Other characters slowly join the Devil Bats and its members are now also balanced by the opposing team.
Sena was a high school student Deimon a weak and timid. Since elementary school, Sena has become a slave by his friends.
Sena also has a childhood friend named Mamori Anezaki (姉崎 まもり, Anezaki Mamori) is always protected when harassed by other children. However, the Sena has very quick feet as they often ran to fulfill orders naughty children, leaving her feet and used to run here and there. Then one day, when the Sena managed to pass the entrance test, he was tricked into Hiruma to get his home address with phone lend Hiruma, the brochure also includes a lot of football clubs in his home, to make the rifle stress. What made him become interested to enter the club because he wanted to be syumu (club managers) are out of compassion with Kurita whose members are only two people. But, over time she eventually became a player excited, too. This is because he has promised Seijuro Shin. When elementary school, Sena has always made a slave by his friends. He always saved by Kaitani Riku, her classmates. Riku has quick feet and he was the one who taught Sena Sena how to run in order not to be disturbed again by his friends. However, Sena instead use his running ability to be faster when errands and make Riku angrily. Unfortunately Riku only two weeks of classes with Sena because her parents changed jobs. Even so, Riku Sena promised to always train the legs to be fast .. He trained with his foot speed running technique taught Riku, for six years, so the faster the speed of his running ability with the speed of light 4.2 seconds. Even with hard work, a team of people who mediocrity, able to beat strong teams capable of winning and Christmast Bowl, the highest competition for high school football tournament. Even Senapun able to provide a balanced resistance, for the American team, the world''s strongest team, he''s Youth World Cup competition. Comics that should be read as full of meaning and educate.