Dr. Richard Kimble is accused, tried, imprisoned and sentenced to death for the murder of his wife. At the time of removal to be executed, the train carrying it suffers a derailment and Kimble escapes from police custody became the country's most wanted fugitive. Since then devotes all its efforts to find the real culprit he considers a one-armed man with whom he clashed in the place where his wife was asesinada.A along their journey through the country to find the murderer of his wife has the opportunity to meet several people who tries to help. At the same time, the inspector must flee Gerard, who relentlessly pursue him in order to fulfill his sentence and he is convinced of his guilt.