When the American territory was still under the control of England James Howlett teenager witnesses the savage murder of his father, John Howlett is murdered at the hands of Victor Creed's father, Thomas Logan, in retaliation murders James Logan, who confesses dying that is his real father, young James and Victor with a promise to take care of each other.
Years passed and the brothers participated in the subcontinent than the Civil War, World Wars and the Vietnam War. In the latter location, Victor tries to rape a woman ends up killing a superior officer who tries to stop him. Along with James are sentenced to death, but thanks to its special regenerative powers come alive.
Then they are contacted by Major William Stryker who urges to belong to an elite commando mutants. In his first mission building access a smuggling of precious stones in Nigeria to recover a meteorite, however, to ascertain the origin of the rock in some places, excessive use of force has to have civilian casualties, something that James fails so he decides to leave the group.
Six years after James Logan in the Rockies is living with his girlfriend Kayla Silverfox, while his brother Victor begins to kill their former comrades in command, Stryker sought urgent assistance from Logan to stop such a big threat but downplayed it . The consequences were swift, Victor comes back on the scene and sacrifices Kayla, Logan is enraged then seeks to avenge his brother but before you go to Stryker who has the perfect strategy to beat Logan, only to return for protect him.
The scientific exercise was to meet with Logan's skeleton with Adamantium Logan (metal indestructible), but in the back was a dirty ploy Stryker who want to make it your particular murder machine, so summoning his new power away. .
Now Logan, hereinafter referred to Wolverine, he learns that Victor is working for Stryker trapping mutants to dangerous experiments and in favor of creating the most powerful weapon in history. It is then that Wolverine on his motorcycle is heading to Vegas, hoping to find that dreadful place, and perhaps one mutant survivor who help. Suddenly he meets Gambit who initially fled believing his enemy but upon learning of his real intentions leads the island where the laboratory.
In that place are surprised to learn that his girlfriend is alive, so Wolverine to see that everything was a ruse to serve the purposes of Stryker, try to leave but to prevent attempts to kill Victor as Kayla faces Victor and hits hard, but not kill him because he still believes that his brother and does not want either to become a murderer.
Kayla comes quickly with the release of hundreds of mutants, the reaction is to release the Striker, "Weapon XI" a mutant with the power of other mutants and Wolverine Victor must unite to defeat him again and eventually decapitating him. When Logan tries to escape with his girlfriend seriously injured, Striker gets shot in the head but not let him kill him unconscious.
On waking Woverine learns that Kayla died, Striker is caught in a dead-end dimension and although Gambit invites you to join a group of mutants who fight to defend and peace with humans, he decides to seek answers and destination.