Helen Magnus runs Sanctuary, a place where people or creatures born different can go. She calls them Abnormals. She's only 157 years old.
Her daughter, Ashley, helps her catch them. Ashley has a few gifts of her own. She's super fast and strong. She has a lot of teenage tendencies, like not doing what she's told and assuming she knows everything.
Will Zimmerman used to work for the police. He never took things at face value because he saw too clearly. He saw what others didn't. This didn't make him popular. Especially when his conclusions don't match what they think happened. He was ridiculed and treated like an idiot. Even though he was actually right,it could rarely be proven.
This is a blend of X-Files, Kolchak:The Night Stalker, Psych, and Lie to Me. And probably others that I don't recognize.
Will is able to tell if a person is lying or what they're feeling by body language. Helen convinces him to join Sanctuary. She wants him to help her help the Abnormals.
As the series progresses you learn how Helen and her friends became different. She found some ancient vampire blood and created a serum that they all took.
Helen remained basically human, just long lived. John Druitt, her lover, became a teleporter. Nicolai Tesla came the closest to being a true vampire.
I haven't finished the series, so I don't know about the other friends.