This paper was performed on
hyperglycemia Lowering effect of a purified fraction of Soybean Isoflavone(SI-Ⅱ)in diabetic mice.
The results showed that after intake of SI-Ⅱ for 12d at adose level of 50～100 mg/(kg·d) continuously, thehyperglycemic mice induced by Alloxan lowered the fasting blood sugar level significantly (p<0.01) as compared with the controls.SI-Ⅱ could enhance insulin concentration of alloxan-inducing diabetes mice significantly (p<0.01) and improve the cardinal symptomsof diabetes mice, such as water-intake, food-intake, protein expression and body weight. SI -Ⅱ could restore the injury of alloxan-inducedpancreas islet observed by histopathological section. The immunohistochemical result indicated that SI -Ⅱ was capable to inhibit theexpression of Fas by pancreas islet. The results also showed that SI-Ⅱ could increase the immune organ weight in alloxan-inducingdiabetes mice remarkably (p<0.01). Meanwhile, SI-Ⅱ could not affect the blood sugar level of normal mice. The studies implied thatrecovering the alloxan-induced β cell damage via the way of inhibiting the apoptosis of the beta cells of pancreas islet and enhancingimmune function might be of the important
hyperglycemia lowering mechanism of SI.