ObjectiveTo investigate the
changes of erythropoieti n( EPO) in both
cerebral cortices and
serum in chronic Aluminum-toxicated rats,and to probe the preventive
effects of the Chinese
herbs.MethodsChronic Aluminum
toxication of rats were induced by intraperitoneally injection with AlCl 3 solution. Changes of cerebral cortices were studied by histochemica l staining. The EPO levels in both cerebral cortices and serum were tested by radi oimmunoassay.ResultsChronic Aluminum toxication damaged neuron al cells of cerebral cortices, and the levels of cerebral EPO decreased signific antly(P<0.05),serum EPO increased significantly(P<0.05).After admini strati on of the Chinese herbs, cerebral damages lessened obviously, but EPO in either cerebral cortices or serum did not changes.ConclusionChronic A luminum toxication plays an important role in the damage of cerebral cells and t he reduction of EPO production. Chinese herbs partly prevent cerebral damages, b ut the effects are not mediated by EPO.
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