Objective: To observe the clinical manifestations and pathological chan ges of drug-induced
renal impairment. Method: 25
cases with drug-induced renal i mpairment were analysed retrospectively, who were confirmed clinically and patho logically. Results: 25 cases included both acute (20) and chronic (5) renal fail ure. In former there were acute renal tubular necrosis (13) and acute interstiti al nephritis (7). And their outcomes were deaths (2), recovered (15) and chronic (3). In latter all 5 cases were chronic interstitial nephritis, resulting in 3 deaths. The
renal impairment related to dosage and couse of treatment for follow ing drugs: gentamicin, contrast media, cisplatin, methotrexate, NSAIDs, longdanx ieganwan, while no such relations were found in ampicillin, cefazolin, ciproflox acin. Conclusion: Dosage and course of the above-mentioned drugs for treatment should be cautioned, together with consideration of patients' age and physical condition, such as dehydration, hypoproteinemia, diabetes, nephrosis, the elderl y and children in particular.