In this paper, the antihypertensive effects of
fucoidan oligosaccharides prepared from Laminaria japonica on renovascular
hypertensive rats (RHR) and related mechanisms are presented.
Renovascular hypertensive rats (RHR) models were made with a two kidney one clip assay and the effects of the
fucoidan oligosaccharides at doses of 6.25,12.5, 25 and 50mg/kg were studied in renovascular hypertensive rats in the acute therapeutic experiment. Arterial blood pressure including systolic blood pressure (SBP) and diastolic blood pressure (DBP), respiration and plasma angiorensinⅡ(AngⅡ) were measured respectively. The results show that fucoidan oligosaccharides can markedly reduce the arterial blood pressure and plasma AngⅡ of RHR and the antihypertensive effects of fucoidan oligosaccharides at high doses are similar to captopril. Moreover, the change of the respiration of RHR is similar to that of their blood pressure. The respiration of RHR had the same change trend as blood pressure. These results indicate that fucoidan oligosaccharides have good antihypertensive effects on RHR and one of the mechanisms underlying the antihypertensive effects might be that they can inhibit the production of AngⅡ.