Vitamin B12 (3)

Vitamin B12 (3)Vitamin B12 SupplementationEffectiveness of vitamin B12 supplementation DENVER, COLORADO. It is estimated that about 16% of older adults are vitaminB12 (cobalamin) deficient. All participants received 25 mcg/day of cobalaminduring the first 6 weeks, 100 mcg/day during the next 6 weeks, and 1000 mcg/dayduring the final 6 weeks of the study. The 1000 mcg/day dose was also effectivein lowering homocysteine level in 75% of the patients, but folic acidsupplementation was required in 4 of the patients in order to bringhomocysteine concentrations down to an acceptable level. He suggests that thedeficiencies not only contribute to the symptoms of CFS but also impair thehealing process. One involves intrinsic factor and is estimated to lead toabsorption of about 60 per cent of the amount of vitamin B-12 ingested in thediet. In 1991 a review of the use of oral cobalamin was published in the Journalof the American Medical Association. Dr. Lederle concludes that themajority of Minneapolis interns are still unaware of the oral treatment option.Journal of the American Geriatrics Society, Vol. 46, September 1998, pp.1125-27Oral administration of vitamin B-12 is effective BRUSSELS, BELGIUM. The conventional way of correcting a vitamin B-12 deficiencyhas been through intramuscular injection of the vitamin. Now researchers at theUniversities of Brussels and Antwerp report that oral administration of freevitamin B- 12 is effective in normalizing low vitamin B-12 levels. Normalizationof low vitamin B-12 serum levels in older people by oral treatment. Journal ofthe American Geriatrics Society, Vol. 45, No. It is synthesized in the cell nucleus fromvitamin B-12 (cyanocobalamin). Now researchers at the HarvardMedical School and the University of Melbourne are about to release the resultsof a phase II trial involving the use of clioquinol in human Alzheimer'spatients. In the process beta-amyloid forms into the long chain of insolubleplaque so characteristic of Alzheimer's. This, in turn, stops the formation ofhydrogen peroxide and thus the destruction of brain cells and also prevents thebeta-amyloid particles from clumping together. There is some concern thatclioquinol depletes vitamin-B12 in the body so vitamin B12 supplementation is amust when taking clioquinol Vitamin B12 deficiency and Alzheimer's diseaseSACRAMENTO, CALIFORNIA. Vitamin B12 deficiency is associated with thedevelopment of megaloblastic anemia, mental dysfunction, and dementiaresembling Alzheimer's disease. Vitamin-B12 (cobalamin) is a very importantcofactor in several biochemical reactions including the conversion ofhomocysteine to methionine and the synthesis of SAMe (S-adenosylmethionine). Itis believed that high levels of TNF-alpha speed up the progression ofAlzheimer's disease thus explaining the association between low vitamin B12levels and Alzheimer's. The researchers point out that the increase inTNF-alpha and the decrease in EGF can both be reversed by vitamin B12supplementation. TNF-alpha is also implicated in the progression of HIV to AIDSand vitamin B12 has been found to slow this progression. Compared withparticipants with normal levels of vitamin B12 and folate the participants withlow levels of at least one of the vitamins had a 2.3 times higher risk of ADand a 1.7 times risk of any kind of dementia. The researchers speculate that homocysteine, a known neurotoxin, may be involvedin the development of AD and that vitamin B12 and folic acid help prevent thiseffect by reducing homocysteine levels in the body.Vitamin B12 and folate in relation to the development of Alzheimer'sdisease. Suspicionhas been growing that a lack of vitamin B12 is somehow implicated in thedevelopment of Alzheimer's disease. They also consider the possibility that thegenetic predisposition to Alzheimer's disease may actually be related to agenetic impairment in the ability to absorb vitamin B12.