OBJECTIVETo improve the rationality of the prophylactic application of antibiotics in
perioperative time. METHODSThe data
of medication of two groups of patients in Mar 1997 and Mar 2001 were collected respectively, and the condition of prophylactic application of antibiotics in perioperative time was compared. RESULTSBy means of reinforcing the management of prophylactic medication in perioperative time, formulating practicable regulations, supervising the feedback results, and conducting intervenient measures, the application of antibiotics in perioperative time was made more regularly and rationally. Iu comparison with that in Mar 1997 group the percentage of preoperative antibiotic medication in Mar 2001 group was lower P<0.001; the percentage of intraoperative medication was higher (P<0.001) and the duration of
postoperative medication was 1-2 days shorter, and the percentage of postoperative medication was up to 100% same in the two groups. There was a trend using more broad-spectrum
antimicrobials for prophylaxis, and the proportion using third-generation of cephalosporins and quinupristin antimicrobials was higher.CONCLUSIONSIn order to administrate antimicrobials rationally and to prevent the postoperative infections, the perioperative administration of antimicrobials for prophylaxis needs to reach a higher level, and the following measures need to be emphasized: to familiarize with the indication of prophylactic medication of various operations; to control preoperative prophylactic medication; to select proper antibiotics for perioperative prophylaxis; to limit the period of postoperative medication; to supervise the administration of antibiotics to the operated patients regularly.