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Shvoong Home>Science>Biology>neurological findings related to fever induction Summary

neurological findings related to fever induction

Article Summary   by:viraj gala     Original Author: Clifford Saper
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The studies conducted by the researchers at Beth Israel Medical Center (BIDMC) have led to the finding of a key site in the brain, the first time,which is responsilbe for the adaptive fever response.
During periods of inflammation, which represents the primary immune response to any infection or illness, body produces cytokines which act on blood vessels in the brain to produce the hormone prostaglandin E2 (PGE2). this hormone PGE2 then enters the brain and acts on a target called EP3 receptor, on neurons, to cause the fever response.

In their studies the scientists at BIDMC created a knockout mouse in which the gene for the EP3 receptor could be removed in one part of the brain at a time.
Published: August 12, 2007   
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