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Shvoong Home>Science>Biology>Dynamic Properties of Network Motifs Contribute to Biological Network Organization Summary

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Dynamic Properties of Network Motifs Contribute to Biological Network Organization

Book Abstract by: PLoS    

Original Authors: Prill Robert J; Iglesias Pablo A; Levchenko Andre
Biological networks, such as those describing gene regulation, signal transduction, and neural synapses, are representations
of large-scale dynamic systems. Discovery of organizing principles of biological networks can be enhanced by embracing the notion that there is a deep interplay between network structure and system dynamics. Recently, many structural characteristics of these non-random networks have been identified, but dynamical implications of the features have not been explored comprehensively. We demonstrate by exhaustive computational analysis that a dynamical propertystability or robustness to small perturbationsis highly correlated with the relative abundance of small subnetworks (network motifs) in several previously determined biological networks. We propose that robust dynamical stability is an influential property that can determine the non-random structure of biological networks.
Published: October 04, 2005
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