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Shvoong Home>Science>Biology>How Does Cross-Reactive Stimulation Affect the Longevity of CD8 - T Cell Memory? Summary

How Does Cross-Reactive Stimulation Affect the Longevity of CD8 - T Cell Memory?

Book Summary   by:PLoS     Original Authors: Ganusov Vitaly V; Pilyugin Sergei S; Ahmed Rafi; Antia Rustom
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Immunological memorythe ability to remember previously encountered pathogens and respond faster upon re-exposure is a central feature of the immune response in vertebrates. The cross-reactive stimulation hypothesis for the maintenance of memory proposes that memory cells specific for a given pathogen are maintained by cross-reactive stimulation following infections with other (unrelated) pathogens. We use mathematical models to examine the cross-reactive stimulation hypothesis. We find that: (i) the direct boosting of cross-reactive lineages only provides a very small increase in the average longevity of immunological memory; (ii) the expansion of cross-reactive lineages can indirectly increase the longevity of memory by reducing the magnitude of expansion of new naive lineages which occupy space in the memory compartment and are responsible for the decline in memory; (iii) cross-reactive stimulation results in variation in the rates of decline of different lineages of memory cells and enrichment of memory cell population for cells that are cross-reactive for the pathogens to which the individual has been exposed.
Published: June 09, 2006   
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