By means of a computer search for upstream promoter elements (distal
sequence element and proximal sequence element) typical
of small nuclear RNA genes, we have identified in the human genome a number of previously unrecognized, putative transcription units whose predicted products are novel noncoding RNAs with homology to protein-coding genes. By elucidating the function of one of them, we provide evidence for the existence of a sense/antisense-based gene-regulation network where part of the
polymerase III transcriptome could control its polymerase II counterpart.