Expanding Roles for
Organoboron Compounds –
Versatile and Valuable
Molecules for Synthetic, Biological and Medicinal
Chemistry by Nicos A.
Petasis
The present essay offers an overview of the latest developments in
the chemistry of organoboron compounds. The unique structural
characteristics and the versatile reactivity profile of organoboron
compounds continue to expand their roles in several areas of chemistry.
A growing number of boron-mediated
reactions have become vital tools
for
Synthetic chemistry, particularly in asymmetric synthesis,
metal-catalyzed processes, acid catalysis, and multicomponent
reactions. As a result, boronic acids and related molecules have now
evolved as major players in synthetic and medicinal chemistry.
Moreover, their remnant electrophilic reactivity, even under
physiological conditions, has allowed their incorporation in a growing
number of bioactive molecules, including bortezomib, a clinically
approved anticancer agent. Finally, the sensitive and selective binding
of boronic acids to diols and carbohydrates has led to the development
of a growing number of novel chemosensors for the detection,
quantification, and imaging of glucose and other carbohydrates. There
is no doubt that the chemistry of organoboron compounds will continue
to expand into new discoveries and new applications in several fields
of science.
Australian Journal of Chemistry 60(11) 795–798
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