Objective To prepare sulindac chitosan gel and apply the drug to the clinic. Methods
Add 5.0 g of sulindac and 50.0 g of glycerin to 500
mL of methanol with stirring for dissolution.Add 400 mL of pure water to the solution for dilution.Cast 10.0 g of chitosan and 5.0 g of carbomer on the surface of the liqid for full-blown swelling followed by the addition of 5.0 g of laurocapram and triethanolarnine qs with strring.Add pure water to 1000 mL with stirring and the gel was completed.Ultraviolet spectrophotometry was used to determine the content of sulindae in the gel.135
patients with
rheumatoid arthritis(RA) were randomly divided into 2 groups: the
trial group(n=75) and control group(n=60).The affected joints in patients of the trial group were smeared with 0.1-0.5 g of the sulindal chitosan gel per joint according to the size of the joints t.i.d..Patients of the control group were given each 0.2 g of sulindac PO,b.i.d..The course of treatment in both groups lasted 8 weeks. Results The average rate of recovery in content determination of sulindac was 100.3% with an RSD of 1.8%(n=5).The overall effective rates in patients of the trial group and control group were 93.3% and 81.7%,respectively(P<(0.05)). Conclusions The quality of the
preparation accords with the relevant regulations of gel preparation of the Chinese Pharmacopoeia.It may thus be used in the clinic.
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