OBJECTIVE:To observe the
stability of
Cefotaxime Sodium For Injection', 1, 1611995)"; href="/tags/cefotaxime-sodium-for-injection/">cefotaxime sodium for injection in PVC
infusion bags,PP plastic infusion bottle,non-PVC multilayer polymer infusion bags and glass bottles.METHODS:Cefotaxime sodium for injection prepared respectively with 0.9% NaCl injection and 5% GS injection were stored under 4℃ and 25℃respectively with PVC infusion bags,PP plastic infusion bottle non-PVC multilayer polymer infusion bags and glass bottles,the appearances of the samples taken respectively at 0h,0.5h,1h,2h,4h,and 6 h were observed,the pH levels of which were detected and the contents of which were determined with UV-spectrophotometry.RESULTS:No significant change was
noted in the detection results of all the items of cefotaxime sodium for injection in 4 kinds of infusion packages and under different temperatures;and no significant difference was noted among 4 groups(P>0.1) except for a concentration reduction by more than 10% in 5% glucose injection in PVC infusion packages at 25℃.CONCLUSION:5% glucose injections in PVC infusion packages should not be used under high temperatures in the clinic.
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