OBJECTIVE:To observe the stability of
cefotaxime sodium for injection in PVC infusion bags,
PP plastic infusion bottle,non-PVC
multilayer polymer infusion bags and glass bottles.METHODS:
Cefotaxime sodium for injection prepared respectively with 0.9% NaCl injection and 5% GS injection were stored under 4℃ and 25℃respectively with PVC infusion bags,
PP plastic infusion bottle non-PVC multilayer polymer infusion bags and glass bottles,the appearances of the samples taken respectively at 0h,0.5h,1h,2h,4h,and 6 h were observed,the pH levels of which were detected and the contents of which were determined with UV-spectrophotometry.RESULTS:No significant change was noted in the detection results of all the items of cefotaxime sodium for injection in 4 kinds of infusion packages and under different temperatures;and no significant difference was noted among 4 groups(P>0.1) except for a concentration reduction by more than 10% in 5% glucose injection in PVC infusion packages at 25℃.CONCLUSION:5% glucose injections in PVC infusion packages should not be used under high temperatures in the clinic.