AIM: On the model of rats tourniquet
shock(ToS), to the
protective effect of
taurine (Tau) on acute
lung injury observe. METHODS: Using the model of ToS, Wistar rats were randomly divided into 3 groups: Control group, ToS group and Tau+ToS group. We observed changes of arterial blood gas level (PO 2, PCO 2) and the values of lung index (LI), lung permeability index(LPI). The activities of xanthine oxidase(XOD) and superoxide dismutase (SOD), Glutathione peroxidase(GSH PX), catalase(CAT) and the contents of ROS, Ca 2+ MDA, MPO in lung tissue were measured. RESULTS: Oral administration of taurine improved significantly the function of lung respiratory,
decreased the activity of enzyme which increased free radicals and increased the activities of the enzyme deleted free radical, inhibited the formation of tissue lipid peroxide, alleviated the edema of tissue and the neutrophil infiltratednkat/g vs (0.020±0.005) nkat/g, P <0.05; (0.018±0.004) nkat/g vs (0.024± 0.005) nkat/g, P <0.05). CONCLUSION: Taurine protected the lung from the ToS ; Increasing the activities of enzyme deleted free radical and decreasing the activities of enzyme generated free radical is one of the protective mechanism of taurine.