AIM: To explore the effects of
taurine on
myocardial blunt injury in rabbits. METHODS: Thirty rabbits were randomly divided into 3 groups: control group, myocardial contusion group(MC group)and taurine treatment group (Tau group). BIM Ⅱ Horizontal Bio impact Machine was used to make the model of myocardial contusion in MC and Tau groups. Ten minutes before and 0.5, 2, 4, 8 and 24 h after impact, blood was taken from femoral vein of the animals to measure the concentration of
serum myocardial tropnion I (
cTnI) and creatine phosphate kinase (CPK). At the 24th hour after impact, the myocardial tissues of all animals were taken to examine the activity of
Atpases', 1, 1605098)"; href="/tags/ca-2%2B-atpases/">
Ca 2+ Atpases. RESULTS: Compared with that of the control group, 2 h after myocardial contusion, the level of serum cTnI and CPK increased ( P <0.05) and the activity of Ca 2+ ATPases in myocardial tissues decreased ( P <0.01) in MC group. Compared with that of the MC group, 8 h to 24 h after impact, the concentration of serum cTnI and CPK obviously fell and the activity of Ca 2+ ATPases in myocardial tissues increased 1 fold in
Tau group. CONCLUSION: Tau can decrease the level of serum cTnI and CPK, and increase the activity of Ca 2+ ATPases in myocardial tissues. Tau can protect rabbits from myocardial blunt injury.