Objective:To observe the effect of
osteopractic total flavone on bone histomorphometry of
osteoporosis model in rath with ovariectomized female rat models. Method:The ovariectomy induced model, bone sliceswith calcium, pigmentation, and Leica Qwin image analysis system were adopted on bone histomorphometry. Result:As compared with the model group, the effect of small
dose group and middle dose group of
Osteopractic total flavone on TBV% of shankbone increased significantly; the effect of small dose group and middle dose group of osteopractic total flavone on TRS% of shankbone
reduced significantly and TFS%, AFS%, MAR, BFR of shankbone reduced obviously; the effect of middle dose group of osteopractic total
Flavone on OSW and mAR reduced obviously, the effect of small dose group of osteopractic
Total flavone on them had the tendency of reducing, but there was no statistical significance. Conclusion:The ovariectomized rats having been fed with osteopractic total flavone for 6 months, TBV% increased significantly while TRS%, AFS%, MAR, BFR, OSW, and mAR reduced obviously. It indicates that the therapeutical effect of osteopractic total flavone on ovariectomy induced osteoporosis model is significant. And the ovariectomy induced osteoporosis model is a high transformative type of osteoporosis model in which bone absorption is higher than bone formation.