Objective To investigate the change in
hepatic and renal functions parameters after
intestinal ischemia-reperfusion(I/R) injury, and to explore the effects of
acidic fibroblast growth factor(
aFGF) on hepatic and
renal functions after intestinal I/R injury in rats. Methods Seventy-eight Wistar rats were divided into four groups, which are sham-operated(C) group, ischemia (45 minutes) plus reperfusion (R), reconstructive human aFGF treatment (rhF), and wild type aFGF treatment (wtF) groups. The animals were sacrificed at 2, 6, 12 and 24 hours, respectively. Hepatic and renal functions was analyzed. Results In comparison with those in group C, the hepatic and renal functions were damaged in group R, rhF and wtF decreased. Treatment with rhF and wtF markedly abated the hepatic and renal dysfunction. The desquamation of intestine villi and infiltration of inflammation cells in the submucosa were observed in all groups. Conclusion Hepatic and renal functions are damaged after intestinal I/R injury. Treatment with rhF and wtF could protect against multiple organ dysfunction associcated with intestinal ischemia- reperfusiun injury.