Objective The
preparation of
ofloxacin ear drop pills.Methods Parallel tests were conducted on the rate of qualified shape and the rate of qualified weight as the index of evaluation,the
orthogonal test was conducted on the 4 factors,including the temperature of drops and the liquor condensate,the drug height in the drug storage
tank and the
dropping distance,accordingly the
optimum forming technics were selected.The content of ofloxacin of main drug was determined with the first order derivative spectrophotometry.Results The optimum forming technics could be seen as follows,the height of the drug storage tank was 3 cm,the temperature of drops was 80 ℃,the dropping distance was 5 cm and the temperature of the liquor condensate was 15 ℃.The concentration (C) of ofloxacin had a linear relationship with the first order derivative UV-absorbance spectorphotometry high (H) in 302 nm:C=229.398 1H-0.120 8,r=0.999 8(n=6);The average rate of recovery was 100.73% and RSD was 0.80%(n=3).Conclusion The preparation is simple in preparation,good in stability;and the quality control method is simple and easy,rapid,accurate and feasible.
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