Aim To prepare
amylopectin anchored dipyridamole(DIP)
liposome and to study its
tissue distribution in mice.Methods The
regular DIP
liposomes were prepared by film-scatter method.The amphiphilic O-palmitoyl amylopectin was synthesized and added to modify the surface of liposome.The entrapping efficiency,zeta potential,mean diameter,span of
modified and regular liposomes were assayed.The RP-HPLC was used for the determination of DIP concentration in mice tissue.Results(After modification),the entrapping efficiency depressed,zeta potential was raised,mean diameter and span had no obvious change.The level of DIP in lung,liver and spleen for regular liposomes were higher than that of injections.Compared with regular liposomes,the modified liposomes increased the DIP level in lung,and decreased the DIP level in liver,spleen,moreover,lengthened the retention time of DIP in lung.Conclusion The distribution of modified liposome in mice was markedly changed as compared with regular liposomes and injections.The modified liposomes had obvious lung targeting property.
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