Objective To investigate the protective effects of the integrated traditional Chinese and western medicine
Xuebijing injection(血必净注射液)
on stressinduced organ damage in
rabbits.Methods Forty rabbits were randomly divided into four groups: the control group,the model group,the western medicine group,and the Xuebijing group.The stressinduced organ damage model was replicated by soak the rabbits in water,the animals in the western medicine group and Xuebijing group received injection of lytic cocktail and Xuebijing,respectively.The changes in cortisol(Cor),thromboxane A_2(TXA_2),endothelin(ET),nitric oxide synthase(NOS) were(determined) at different time points in all the groups.The pathologic changes of the gastric mucosa,the adrenal gland and the cardiac muscle cell were observed.Results The content of Cor increased significantly in model group(P<0.01).The content of Cor decreased in the(western) medicine group and Xuebijing group,the changes showed no significant difference between two groups(P>0.05).The contents of ET,TXA_2 decreased and NOS increased in Xuebijing group compared with the western medicine group,the differences were significant(all P<0.05).The pathological changes of the gastric mucosa,the adrenal gland and the cardiac myocyte were less marked in Xuebijing group,(compared) with the western medicine group,the difference was significant(P<0.05).Conclusion (Xuebijing) has better protective effects on stressinduced organ damage.