Objective To measure the
pharmacokinetics of
piracetam in rats,a major component in the
powder injection of the piracetam compound and study the influence of another component
meclofenoxate on piracetam pharmacokinetics as well as the
Pharmacokinetic variations in rats from different dosages of piracetam.Methods The plasma concentrations were measured by RP-HPLC and the relative pharmacokinetic parameters were calculated after the i.v.injection in rats of different dosages of piracetam single and piracetam compound powder injection.Results The in vivo process in rats after i.v.injection of high,medium and low dosages(150,100, 50 mg·kg~ -1) of piracetam sample and piracetam compound powder injection ( 100 mg·kg~ -1) accorded with the two-compartment model.The major pharmacokinetic parameters such as t 1/2β,AUC,were (160.4±25.8) min,( 15 666.1± 1 785.4) min·mg·L~ -1 respectively upon the i.v.dosage of piracetam compound at 100 mg·kg~ -1,which showed no conspicuous variation from those of piracetam sample at the same dosage.Conclusions Meclofenoxate,another component in the powder injection of piracetam and meclofenoxate,does not influence the pharmacokinetics of piracetam,the major component.The pharmacokinetics of piracetam in rats is of the linear pharmacokinetic characteristic.