Objectives: To study the mechanism of
Yanlieping Formula in treating chronic nonbacterial
prostatitis. Methods: Thirty-two
C57BL/6 mice were divided into Chinese Traditional Medicine group(
Yanlieping group,10 mice), treatment control group(Cernilton group, 10 mice), model group(6 mice) and normal group(6 mice). The animal model was created by using immunologic adjuvant, and Yanlieping ( 0.84 g per mouse), Cernilton ( 7.5 mg per mouse), distilled water( 1.05 ml per mouse) and distilled water ( 0.5 ml per mouse) were respectively administered to the four groups every day for one month. The prostate weight, pathological changes, TNF-α and IL-2 in serum were observed. Results: The prostate weight in Yanlieping group and Cerniton group became significantly lower than in the model group(P< 0.05). Pathologic sign of chronic inflammation became better significantly(Yanlieping group showed more significant improvement). The expression of IL-2 in Yanlieping group and Cernilton group were downregulated significantly. And the expression of TNF-α in Yianlieping group was higher than that of the model group and the normal group (P< 0.05). Conclusions: The mechanism of Yanlieping Formula in treating chronic
prostatitis may lie in the max urethral close pressure reduction, anti-inflammation, local blood circulation improvement.