Aim To prepare
salcatonin dry powder inhalations (sCT DPIs) A (mixture of mannitol and L
leucine) and B (mixture of manntiol and lactose) by
spray drying and then to study their main
pharmaceutical properties. Methods Dumping rate of sCT DPIs capsules and deposited fraction of sCT at effective part were determined according to Chinese Pharmacopiea 2000. Particle morphology under different relative humidity (RH) was observed by scanning electronics microphotograph, particle size and its distribution were determined by Malvern Mastersizer and the transition of morphorous state for
carriers before and after spray drying was investigated by differential thermal analysis (DTA) and X ray powder diffraction (XRPD). Results Dumping rates of sCT DPIs A and B capsules were both above 10% and deposited fraction of sCT at effective part was above 90% for both A and B, which were all in agreement with the standard of Chinese Pharmacopiea 2000. Powder particle of sCT DPIs A was round and existed one by one after keeping one month under RH 0, 23% and 52%, but aggregation can be observed under RH 75%; many particles which were also round agglomerated in sCT DPIs B even under zero RH; mean particle size of sCT DPIs A was 1 67 μm, which was much smaller than that of sCT DPIs B; In sCT DPIs A particle with empty core which was lighter than the same size particle with concreted core was observed. It was shown by DTA that melted heat of L leucine in sCT DPIs composed of mannitol and L leucine lowered much more than that of L leucine exisited alone after spray drying. It was confirmed by XRPD that diffraction intensity of carriers in sCT DPIs decreased more than that of carriers before spray drying. Conclusion Round particle can be made when mannitol was added to carriers and ultra low density carriers can be formed when L leucine was added. It was suggested by SEM that DPIs should be kept under certain RH. Particle size and distribution of sCT DPIs all accorded with demand of DPIs. Complex spray drying carriers formed amorphous state easier than single carrier.
More abstracts about the Preparation and pharmaceutical properties of salcatonin dry powder inhalations