Purpose:The aim is to observe the effects of polysaccharide from Spirulina platensis (PSP) on hyperglycemia and hyperlipidemia
in alloxan induced
diabetic rats.Methods:The diabetic model rats were established by intra abdominal injection of alloxan.Then the living diabetic rats were divided into four groups.Among them,two groups were treated with PSP 0.1 ,0.2 g/kg respectively by ig administration, and one group was given phenfomide 0.35 g/kg by ig adminstration as the positive
control,and another group was given normal saline as the diabetic model control.The normal control group was tested on the normal rats by ig saline.After 14 days of treatment,the blood glucose and the serum lipids content of each group were detected.Results:Compared with the diabetic model control group,PSP 0.1 and 0.2 g/kg could significantly decrease the blood glucose in diabetic rats( P< 0.01).At the same time,the results also showed that PSP could remarkably decrease the level of serum TC,TG and LDL C in diabetic rats.In addition,PSP 0.2 g/kg could obviously increase the serum contents of HDL C in the rats ( P<0.05 ),but PSP 0.1 g/kg had no significant effects on serum HDL C in diabetic rats.Conclusion:PSP had significant effects on hypoglycemic and hypolipidemic action in diabetic rats induced by alloxan.