Objectives:
Cisatracurium is one of the ten isomer of atracurium. Both the preclinical and
premier clinical studies
have suggested that it may be relatively an ideal intermediate
nondepolarizing muscle relaxant. However, repeated studies are required to find out its
advantages and disadvantages, especially by comparing with atracurium. The purpose of the
present study is to evaluate its neuromuscular blocking effects by comparing with atracurium.
Methods: 30ASA patients undergoing selective surgery under nitrous oxide/opioid/propofol
anesthesia were randomly allocated into three groups: Cis1(n=10)Cis2(n=10) and Atr(n=10).
Cisatracurium 01mg/kg(2ED95)015mg/kg(3ED95) or atracurium 05mg/kg(2ED95) was given
respectively. HR BP skin flushing and TrainofFour(TOF) reponse of the adductor pollicis muscle
following supramaximal electrical stimulation of the ulnar nerve were monitored until T4T107.
Results: No significant changes of HRBPwere found in three groups. Onset time of Cis1Cis2
and Atr were5609scular block4008and 2506, clinical duration were 4002545692 and 38445,
respectively. 25%75% recovery index was 1081112620and 9830respectively. Conclusion: At
equipotent dose, the onset time of cisatracurium is slower than that of atracurium but lager dose
can reduce the difference. They have a similar recovery profile and show no accumulation.