Objective\ To observe the long term toxicity of
anti neurasthenia medicine on experimental rats. \ Methods The anti
Neurasthenia
medicine was administered to the rats which were divided into high dose group (34 200 mg/kg),middle dose group (10 300 mg/kg), and low dose group (1 100 mg/kg) for 90 d. Physiological saline was given to the rats in the control group. Hematological,hemato biochemical,visceral,systematic postmortem and pathological examinations were done for 14 rats of each group. The rest of the rats were left for reversible experiment.\ Results\ The effects on hematology and hemato biochemistry and viscera index were not significantly different( F=0.010 6-2.675 1,P >0.05)among the four groups. No abnormal changes were found in the histology of the heart,liver,spleen,kidney,adrenal gland,thymus,thyroid,stomach,intestines,testes,uterus and other organs of the rats in the medicine groups. \ Conclusion\ Long term oral application of the
anti neurasthenia medicine has no harm and no toxic effect on rats.