Labelling conditions with 99m Tc and biobehavior of five
small molecular compounds that have hydroxyl and carboxyl
groups in structure are preliminarily studied. The labelling yields of citric acid (Cit), tartaric acid (Tar), DL malic acid ( DL Mal), L malic acid ( L Mal) and D glucaric acid ( D Gca) are all more than 90 % according to the best conditions. The biodistributions of them and 99m TcO - 4 (P) are studied in mice with turpentine induced abscesses at 1,3 and 6h after 99m Tc labelled compounds i.v.injection. The results demonstrate that the maximum a m (A)/a m (M) ratios are 4.02±0.21(Cit,3 h), 3.20± 0.17 (Tar,1 h), 4.04±0.21( DL Mal,6 h), 3.50±0.23( L Mal,1 h), 4.30±0.77( D Gca, 3 h ) and 3.23±0.41(P,1 h)respectively. Therefore, they all have the biobehavior accumulating in inflammation lesions. Of them, 99m Tc Cit is used in clinic abroad, 99m Tc D Gca is probably a potential
imaging agent on inflammation lesions and further study is needed.