Objective To study the targeted brain distribution of FM-HSA-MTX
carriers under
magnetic guidance and side-effects of the
carriers on liver, kidney and bone marrow. To provide reliable evidence for
magnetic targeting chemotherapy for malignant glioma.Methods Fifty Kunming mice were used. FM-HSA-MTX
carriers were injected into the mice regularly via tail vein. Magnetic field was placed near the right brain of mice. The mice were observed for 3 months. The mice blood was taken out regularly to determine RBC, WBC, BPC, SGPT and NPN respectively. Results At 7 d and 14 d, RBC (935.0±79.2), (925.0±81.5),ALT, NPN had no obvious change in magnetic targeting group (FM-HSA-MTX group), while RBC (570.0±82.2), (505.0±81.2), SGPT and NPN changed evidently in MTX group (P<0.01). Conclusions Under magnet guidance, FM-HSA-MTX carriers was distributed to brain targeting area, which may change the characteristics of MTX flow distribution. The collection of MTX was reduced in liver, kidney and bone marrow, alleviating the damage to them.