To study the effect of obesity reducing drug Kintop on gastrointestinal movement in rats. Methods: Eighteen Wistar rats
were divided into high dose (200mg/100g) Kintop group, low dose (125mg/100g) Kintop group, and control group. After anesthesia,
stomach emptying time was directly observed using methylene blue as indicator. The frequency and amplitude of
intestinal movement, and movement speed of intestinal content were detected. The serum tumor necrosis factora (TNFα) level was measured by ELISA. Results: After administration of Kintop, the stomach emptying time was prolonged markedly, movement speed of intestinal content accelerated, time of dejection increased, the intestinal movement frequency and amplitude increased. There was a negative correlation between intestinal movement frequency and serum TNFα level (r=-0 91,P<0 05). Conclusions: Kintop could significantly prolong the stomach emptying time, accelerate intestinal movement. These effects are correlated with not only the increased time of dejection but also the lowered serum TNFα level.