Objective: To investigate the effects of total base of
Sophora alopecuroides on expression of SOD,MDA,NO,MPO in rats with
experimental colitis(UC).Method: SD rats were randomized into 6 groups and colitis was induced by administrating 2,4,6-trinitrobenzesulphonic acid(TNB) recatlly in rats.Rats were given drug by stomach after the first day for 3 weeks,and sacrificed at 23~(rd) day to determine the content of MDA and activities of SOD,NO,MPO in colonic mucosa,and to estimate the symptom and colonic histology. Result: In UC rats,SOD was significantly decreased whereas MDA,NO,MPO were increased when compared with the normal group(P<0.05).In all treatment groups,
Sophora alopecuroides could increase SOD,decrease MDA, NO,MPO(P<0.05),and improve the symptoms and histological damages.Conclusion: The total dose of S.
Alopecuroides may ameliorates or alleviate the symptoms of UC through inhibiting oxygen free radical reaction,decreasing the generation of NO and exerting anti-inflammatory effects.