Objective: To observe the anti-tumor activity of the ethanol extracts of
Solanum lyratum in vitro and in vivo.Method: In
vitro,the inhibitory effects of ethanol extracts of S.lyratum on proliferation of human hepatoma BEL-7402 cell and gastric carcinoma SGC-7901 cell were measured by MTT colorimetric assay.The mouse tumor model was used to investigate the effects of ethanol extracts on tumor growth.Result: The studies demonstrated that ethanol extracts of S.lyratum inhibited proliferation of BEL-7402 cells and SGC-7901 cells,and the IC_(50)values on them were(287.40±5.84) μg·mL~(-1) and(176.14±5.18) μg·mL~(-1),
respectively.The tumor inhibitory rate of high doses of ethanol extracts on S180 sarcoma-transplanted mice and H22 hepatic cancer were(41.15±4.54)% and(45.00±7.37)%,respectively.When the dose of ethanol extracts varied from low to high,it was able to inhibit the growth of S180 sarcomatransplanted mice and H22 hepatic cancer in a dose-dependent manner.Conclusion: In tumor inhibitory test,it was shown that the ethanol extracts of S.lyratum may possess significantly inhibitory effect in vitro and in vivo.No acute toxic effect was found in our experiment.