To observe the antitussive and antiasthmatic actions of Nervilia fordii (Hance) Schitr. (NF). NIH mice were randomized into 8 groups: 3 NF water- extract groups and 3 NF ethanol-extract groups in high, moderate and low doses (19.2, 9.6 and 4.8 g·kg-1·d-1 respectively), positive control group (codeine phosphate 50 mg·kg-1·d-1 in the antitussive experiment and theocin 0.1g·kg-1·d-1 in the antiasthmatic experiment) and model group. Mice cough models induced by ultrasonic spray of ammonium hydroxide and guinea pigs asthma models induced by ultrasonic spray of histamine-acetylcholine mixture were adopted to observe the antitussive and antiasthmatic actions of NF. Water-extract and ethanol-extract of NF in three doses decreased the cough frequency in mice, and ethanol-extract of NF in three doses prolonged the cough latent period (P<0.01 compared with the model group). In guinea pigs, ethanol-extract of NF in three doses as well as the NF high- and moderate-dose water-extract prolonged the latent period of spasm-tumble, and ethanol-extract NF in low- and moderate-doses and NF high-dose water-extract prolonged the latent period of dyspnea (P<0.05 or P<0.01 compared with the model group). NF has certain antitussive and antiasthmatic actions.
Published: February 28, 2006
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