Marine organisms are a rich source of structurally novel and biologically active metabolites.So far,many chemically unique
compounds of marine origin with different biologically activity have been isolated and a number of them are under investigation and/or are being developed as new pharmaceuticals.In this report,we describe the screening of ethyl acetate extracts of eighty-three strains of
marine sediment fungi,collected from west of the Pacific Ocean beside the equator,for antimicrobial and antitumor activities.As a result,thirtyseven strains showed inhibition against one or more of those tested microorganism,namely EC,SA,BS,CA,ANS,while twenty-nine strains of fungi demonstrated antitumor activity againnst KB cell or Raji cell
respectively.The ratio of such activity fungi to total tested fungi was 44.6%,34.9%.Furthermore,five fungal extracts,namely WP-M-1、DY-G-2、DY-C-2、WP-K-3 and P-Q-2,were chosen to study the IC_(50) against Raji cell,the value of them was 5.000,1.064,2.796,1.920,0.520μg/mL respectively.These results indicated that marine sediment fungi would be a promossing resourse of antimicrobial and antitumor medicament.