ObjectiveTo investigate the effects of
Yiqi Jiangzhuo Decoction (YJD) on transforming growth factor-β_1 (TGF-β_1) mRNA
expression
in treating ventricular remodeling in viral myocarditis. MethodsAfter being established into chronic viral myocarditis model by 4 times repetitively infecting with gradient multiplicative CVB3m, 160 male mice were divided into the blank group, the model group, the TCM treated group and the Western medicine treated group. On the 10th, 30th and 60th day after the last time of infection, mice were killed to observe their pathological changes of myocardium with HE staining and to detect TGF-β_1 mRNA
expression in myocardial tissue with semi-quantitative RT-PCR method. ResultsPathological changes of myocardium alleviated, and TGF-β_1 mRNA expression distribution area reduced significantly in the two treated groups, as compared with those in the model group (all P<0.05). ConclusionYJD could inhibit the hyperplasia and reconstruction of ECM by down-regulating TGF-β_1 mRNA expression to improve cardiac pathological changes in myocarditis, so as to prevent the occurrence of ventricular remodeling and the conversion of disease to dilative cardiomyopathy.