Objective: To study the protective effects of polysaccharide of Spirulina platensis and Sargassum thunbeergiion vascular
of alloxan (ALX) induced diabetic rats. Method: With the doses of polysaccharide of Spirulina platensis(PSP) and Sargassum thunbeergii(PST)
compound(1∶1) 12.261, 36.783,110.349 mg·kg~-1 by ig administration to alloxan induced diabetic ratsrespectively for 6 weeks. Then the blood glucose and the TC, HDL-C,TG, NO,ET in serum were detected. The contraction and relaxation response to NE and ACh in aortic rings of the alloxan induced diabetic rats has been studied. Result: The results showed the compound of PSP and PST could decrease the blood glucose and the TC,TG, NO, ET in serum and increase HDL-C than in the alloxan induced diabetic rats. The contraction
responses to NE in aortic rings of the alloxan induced diabetic rats weresignificantly elevate in the normal rats, and the responses to ACh weresignificantly lower. PSP and PST compound could significantly lower the responses to NE and significantly elevate the responses to ACh in aortic rings of the alloxan induced diabetic rats. Conclusion: PSP and PST compound could decrease blood glucose and could protect the vascular of alloxan induced diabetic rats. <