Objective:To explore the effect of astragalus membranaceus on Ca 2+ ATPase in the myocardium and
calcium ions content
in
vascular smooth muscle in spontaneously hypertensive rats.Methods:Ninteen Spontaneously Hypertensive Rats and sixteen Wistar kyoto Rats were respectively divided into four groups at random,control group,small dose of astragalus
membranaceus group,moderate dose of astragalus membranaceus group,large dose of astragalus membranaceus group. Astragalus membranaceus groups were intraperitoneally administered astragalus membranaceus parenteral solution 0.9ml,1.2ml,1.8ml respectively and control group were given 0 9% sodium chloride injection dakly for eight weeks.Measure the SERCA in the myocardium and the calcium ions content in vascular smooth muscle.Results:The SHR's SERCA in the myocardium was lower than WKY in the control group and that in large dose of astragalus membranaceus group was higher than the SHR's SERCA in control group significantly.We also found that the calcium ions content in vascular smooth muscle in SHR was higher than in WKY in the control group and that in SHR of the large dose of astragalus membranaceus was lower than WKY of the control group significantly.Conclusion:The large dose of astragalus membranaceus can increase the SHR's SERCA in the myocardium and reduce the SHR's calcium ions content in vascular smooth muscle significantly.