Objective:To investigate the pharmacological mechanism of Semen Litchi water extract (SL) on enhancing insulin sensitivity
in type 2 diabetic rats (T2DR) with
insulin resistance (IR).Methods:The effects of SL were observed on serum contents of fasting glucose (FSG),blood urea nitrogen (BUN),creatine (Cr),total proteins (TP),albumin (A),malondialdehyde (MDA),total cholesterols (TC),triacylglycerol (TG),free fatty acid (FFA),leptin,tumor necrosis factor-α (TNF-α),fasting insulin (Fins) and index of insulin sensitivity (ISI),and activities of superoxide dismutase (SOD),alanine aminotransferase (ALT),aspartate aminotransferase (AST) in T2DR-IR.Results:In T2DR-IR, SL could lower concentrations of FSG,TC,TG,FFA,leptin,TNF-α and Fins (P<0.05～0.01) ,increase ISI (P<0.01),reform the
hyperinsulinemia and insulin sensitivity, decrease the levels of BUN,Cr and the activities of ALT,AST,increase concentration of TP,A (P<0.05～0.01),recover the hepatic and nephric functions, increase the activity of SOD and decrease content of MDA (P<0.01). Conclusion: SL could reduce the levels of TNF-α,hyper-leptinemia and hyperinsulinemia,antagonize insulin resistance,fortify insulin sensitivity,readjust lipodystrophy and maladjustment of glycometabolism,enhance antioxidation,and improve functions of liver and kidney in T2DR-IR.