This paper defines the term depression as a psycho-neurotic or psychotic disorder marked by sadness, inactivity, difficulty
in thinking and concentrating, as well as feelings of dejection and hopelessness which can lead to suicidal tendencies. This paper supplies relevant published data and statistics pertaining to this specific topic. This paper discusses the
significant increase in reported cases of severe depression. Currently, the risk of developing depression stands between 8%-12% for men and 20%-26% for women. This paper cites the findings of the World Health Organization which states that by the year 2020 severe depression will be the world's second most debilitating disease, surpassed only by heart disease. The writer contends that, although the exact causes of depression have not yet been determined, it is clear that biological, genetic and
environmental factors play a significant role. Some common environmental factors linked to depression include involvement in difficult relationships, conflicts with family members, friends and co-workers and/or the death of a loved one. This paper explores the various treatments available including: Electro-convulsive therapy, psychotherapy and drug therapy while also citing the success rates for these and other treatments. Table of Contents: Abstract Major Depressive Disorder Epidemiology Etiology Diagnosis and Clinical Presentation Mental Status Exam Comorbidity and Differential Diagnosis Course and Prognosis Treatment Summary Conclusion References