Objective To study the effect of Fufangbiejiaruanganpian (FFBJRGP) on
deposition of collagens around
hepatic Disse space in experimental alcohol
liver fibrosis (ALF). Methods The ALF rat model was induced by feeding a mixture of
alcoholic liquid which included alcohol, vegetable oil and pyrazole, combined with a high fatty food. Then, all of the ALF rats were treated with FFBJRGP in high, moderate, and low dose. At the time of termination of the
treatment, HYP level in liver tissue,
collagen Ⅳ and LN levels in the serum and pathological changes were studied by Mallory stain and sirius red stain. Results The levels of HYP in hepatic tissues, collagen Ⅳ and LN in sera are increased remarkably in ALF rats, while all these indexes were reduced after moderate or low-dose FFBJRGP treatment (P<0.05 or P<0.01). Much collagen deposition was found around the Disse space, and a large amount of Ⅰ
type collagen was also observed in the central vein or 3rd area of hepatic acinus. After the treatment with FFBJRGP, the collagen level was decreased distinctly ,and the type of collagen in the Disse space was changed from type Ⅰ to type Ⅲ. Conclusion FFBJRGP might suppress the collagen synthesis and deposition in hepatic Disse spaces to prevent the capillization of hepatic sinusoids, as well as promote the collagen transformation from immaturity to maturity, thereby blocking the process of the liver fibrosis effectively.
More summaries about the Effects of FFBJRGP on collagen deposition in hepatic Disse space in alcohol induced liver fibrosis i